T 26 - Beyond 32-34
1. How did James Rockwell and his subject cohorts sabotage their drug study?
2. Why is speed critical in getting drugs approved and on the shelves as early as possible?
3. What motivated homeless alcoholics to participate in trials for Eli Lilly, according to its director of clinical pharmacology?
4. Guinea pigs rely mainly on what to insure their safety?
5. The target audience for the jobzine Guinea Pig Zero was who?
6. DARPA projects include research on drugsto keep soldiers awake and fed for how long?
7. Radiation exposure from nuclear testing on American soil in the '50s was comparable to what?
8. Fear of chemical weapons during the Gulf War led to the administration of what vaccine prior to FDA approval?
9. Gulf War vets and their children have been diagnosed with what?
10. What percentage of DARPA projects fail?
11. How did New York city law enforcement officials help researchers in the mid '90s?
DQ
- Should "guineau-pigging" be a job?
- For how long should drug patents be issued?
- Have you participated in any drug trials? Do you want to?
- "What happens when both parties involved in a trial see the enterprise primarily as a way of making money?" 292
- Are for-profit IRBs inherently compromised?
- COMMENT on the Susan Endersbe case. 295
- How should test subjects be procured? Should there be a cap on how much doctors can earn for procuring them?
- How would you fix our "patchwork regulatory system"? 300
- Should medical research aimed at enhancing soldiers' competence, stamina, and endurance be held to different ethical standards? Is all really fair in (love and) war?
- Is there an ethically-defensible military rationale for "race-based" or "man-break" tests? 302
- What's your response to any of the questions at the top of p.302?
- Should all soldiers be required to sign waivers allowing the administration of any drugs deemed necessary or appropriate? Does military service tacitly allow drug experimentation in the interests of "national security"?
And speaking of DARPA...
Th 28 - Beyond 35-36 [no class today]
1. "Gen IVF women" like Miriam Zoll began thinking what, in the 70s and 80s, about their prospects for motherhood?
2. Women who experience failed fertility treatments often exhibit symptoms of what?
3. The ART failure rate for American women over 40 in 2012 was what?
4. How much does surrogacy typically cost in the U.S.?
5. Zoll and her husband were "aghast" at what, during their search for an egg donor?
6. What has become a cultural expectation for many LGBT people?
7. What's the Internet's role in fashioning "queer intimacies"?
8. Who fills the need of outsourced surrogacy?
9. Artificial gametes and cloning would not help who, but would negatively impact who?
10. New reproductive technologies provoke a rethinking of kinship markers while raising what questions?
DQ
- Why do so many couples have an "obsession to procreate"? Would they be well-advised to try and re-direct that obsession to parenting (and perhaps adopting)?
- COMMENT on any of the "ten things I wish someone had told me..." (323 f.)
- COMMENT on the "new grounding assumption..." (329)
- COMMENT on any of the questions at the bottom of p.334.
Alt quiz q's
ReplyDelete1. After initially utilizing academic health centers, pharmaceuticals have moved trials to the private sector, where more than __ percent of them are now conducted. 291
2. A Holiday inn was the site for what pre may 2006? 292
3. Who was Susan Endersbe? 295
4. Detail the misconduct of Faruk Abuzzahab. 294-296
5. According to the NEJofM, only 16 percent of academic medical centers in the U.S. provided what? 298
6. What are "man-break" tests? 302
7. Describe the use of SSRIs in the military. 307
8. What is the "persistent in combat" program? 308
9. What is the "augmented cognition program"? 308
10. What is the feres doctrine? 310
6.a gas experiment where service men were kept in a chamber filled with mustard gas until they became incapacitated.
Delete7."for depressive disorders and anxiety disorders." dosed in high quantities without definitely proved clinical benefits
8. A program that aims to create unstoppable soldiers through the control of pain, wounds and bleeding.
9. DARPA attempting to create technologies that measure and track cognitive states of an individual as it happens.
10. A composed pile of claims of experimental research that has disregarded ethical protocol.
1. For the past few decades who has been the primary mechanism for protecting subjects at drug trials? (293)
ReplyDelete2. In 2005, what were FDA inspectors finally given? (294)
3. The FDA inspects ____ percent of clinical trials. (294)
4. What are some of the negative outcomes for individuals who participated in clinical trials as mentioned on page 294?
5. On what is the US regulatory system built? (296)
6. What percent of clinical researchers were affiliated with academic research centers according to the Tufts Center for Drug Development and how had that changed in 2006? (296)
7. What was found when “another top recruiting investigator” arrested? (297-297)
8. Who created Guinea Pig Zero and why was he qualified to start this “jobzine for research subjects)? (297-298)
9. The occupation of being a guinea pig comes with “compensation” but are not given what? (298)
10. When illegal immigrant guinea pigs at SFBC talked to the press, managers threatened to do what? (299)
6.70%, and by 2006 that number dropped to 36%.
Delete7.A loaded semiautomatic weapon and cocaine
8. Bob Helms, he was a pioneer in the guinea pig activism and worked as a care giver once.
9. wages
10. to have them deported
This comment has been removed by the author.
ReplyDeleteShould "guinea-pigging" be a job?
ReplyDeleteI do not believe that this should be a job for people. However, I do realize that researchers need test subjects and there is a kind of necessity to these "Guinea Pigs" because they provide the much needed data that is required to advance medicine. I personally would like to see some other way of fulfilling this need for researchers, but I cannot think of any ideas to replace "Guinea-Pigging". Does anyone else have an idea for this?
Alt QQ's and Discussion:
ReplyDelete1. According to the New England Journal of Medicine, what percent of industry-sponsored trials were run in academic health centers? (290)
2. Why did Faruk Abuzzahab have to take a class in medical ethics? (295)
3. What has the safety of new drugs always depended on? (300)
4. What did the Project BioShield act of 2004 grant? (307)
5. What trial did the FDA renew in 2009? (315)
1. Should "Guinea Pigs" be given higher wages like Helms argues in "Guinea Pig Zero", or no money at all as argued by ethicists and regulators? (298)
2. Why do you think that there are still a large number of nonconsensual ongoing and what are your ideas to change and regulate this? (315)
DQ: Should "guinea-pigging" be a job?
ReplyDeleteGuinea-pigging really shouldn't be a job for a variety of reasons. I have no problems with people getting paid to be test subjects. It can be hard for drug companies to find volunteers for trial runs, especially if their product isn't geared toward some kind of well-known illness or condition. The trouble can arrive with professional guinea pigs who have undergone many experimental procedures or drug trials. The long-term effects of these studies may not be well understood by the time that they participate in new experiments. These conditions may be benign when experienced one at a time, perhaps even unnoticed, but accumulated side-effects might jeopardize their health and cause false results in other drug or procedure testing. After a while, it may become difficult to know whether or not the test material was the cause of any outcomes, whether good or bad, or the results were actually from the combination of different procedures interacting in ways unconsidered. Professional guinea pigs may be useful for a while, but if they stay for very long, they risk putting the results of some potentially helpful products into question.
The ten things were enlightening about the field that I almost was a part of. When I researched the responsibilities of a genetic councilor, much of it was psychological assistance, tempering both fears and excitements. Not every egg and sperm is made perfect even though that is what clinics strive for. The emotional toll was not a surprise. There is a vulnerability in that situation that unless you were in the same or similar situation, it is impossible to understand those emotions.
ReplyDeleteAlternative Questions:
ReplyDelete1. The first test tube baby was born in the year _______ and the first donor egg baby was born in the year ______. (321)
2. Fewer than ______ clinics in the United States have signed up for the Infertility Family Research registry? (325)
3. Name the world’s first fertility company. (326)
4. _______ ________and ______ ________ are a booming business. (326)
5. In what year was the first pregnant man introduced to the world? (328)
6. Fertility Inc., consist of what? (332)
7. What was one of the bioethical dilemmas raised on page 334?
8. In the U.S., ___________ of ownership and individualism punctuate reproductive practices and services? (334)
9. How is biomedicalization stratified? (333)
10. Social issues are increasingly being defined as what? (333)
Alternate Quiz questions:
ReplyDelete1. Hiw many chapters does Miriam Zoll's story have? (322)
2. During the years Miriam Zoll underwent IVF, what were the women she met addicted to? (322)
3. What did Miriam Zoll constantly think when cycle after cycle of IVF failed? (324)
4. What activities are stunningly unregulated in fertility clinics? (326)
5. Why was it much more difficult for Mirian Zoll to decide to use donor eggs instead of IVF? (327)
6. The emergence of lesbian reproduction was enabled through what? (329)
7. What was a central finding posed in "Queering Reproduction"? (329)
8. What continues to be shaped by structural intimacies according to Mackenzie in 2013? (331)
9. What technologies are a part of the Wild West medicine? (333)
10. In the US, what ideals pubctuate reproductive practices and services? (334)