Sunday, November 28, 2021

Could Covid Lead to Progress?

Mass tragedies sometimes have unexpected consequences.

...Of course, for meaningful lessons to be learned from a tragedy — whether a factory fire or a pandemic — you have to begin by acknowledging the facts of the event itself. The rise of Covid denialism, in America and elsewhere, is often taken as a reason to doubt that any progress will grow out of the tragedy of Covid-19. But as depressing as anti-science belligerence can sometimes be, there is abundant evidence that we are learning from this epidemic. To begin with, the period from March 2020 to May 2020 almost certainly marked the most significant short-term change ever in worldwide human behavior. Vast sections of the planet effectively froze in place for a few months, and then adopted, en masse, a whole new set of routines to flatten the curve and slow the spread — a genuinely new trick for Homo sapiens. It was not obvious in advance that such a thing was even possible.

Imagine, if you can bear it, what happens the next time word emerges of a novel virus devastating a midsize city somewhere in the world. The slow-motion reaction that characterized the global response to the news from Wuhan in early 2020 would be radically accelerated. Even without public-health mandates, a significant part of the world’s population, particularly in cosmopolitan cities that were hit hard in the early days of Covid, would instantly mask up; where possible, workers would switch back to Zoom; unnecessary travel would cease. No doubt some portion of the population would play down the magnitude of the threat or invent a preposterous conspiracy theory to explain it. But a meaningful number of people would switch back into the “pandemic mode” they learned in 2020-21...
https://www.nytimes.com/2021/11/22/magazine/covid-progress.html?smid=em-share

The Gene-Synthesis Revolution

Researchers can now design and mass-produce genetic material — a technique that helped build the mRNA vaccines. What could it give us next?

...In a way, that future has arrived. Gene synthesis is behind two of the biggest “products” of the past year: the mRNA vaccines from Pfizer and Moderna. Almost as soon as the Chinese C.D.C. first released the genomic sequence of SARS-CoV-2 to public databases in January 2020, the two pharmaceutical companies were able to synthesize the DNA that corresponds to a particular antigen on the virus, called the spike protein. This meant that their vaccines — unlike traditional analogues, which teach the immune system to recognize a virus by introducing a weakened version of it — could deliver genetic instructions prompting the body to create just the spike protein, so it will be recognized and attacked during an actual viral infection.

As recently as 10 years ago, this would have been barely feasible. It would have been challenging for researchers to synthesize a DNA sequence long enough to encode the full spike protein. But technical advances in the last few years allowed the vaccine developers to synthesize much longer pieces of DNA and RNA at much lower cost, more rapidly. We had vaccine prototypes within weeks and shots in arms within the year.

Now companies and scientists look toward a post-Covid future when gene synthesis will be deployed to tackle a variety of other problems. If the first phase of the genomics revolution focused on reading genes through gene sequencing, the second phase is about writing genes. Crispr, the gene-editing technology whose inventors won a Nobel Prize last year, has received far more attention, but the rise of gene synthesis promises to be an equally powerful development. Crispr is like editing an article, allowing us to make precise changes to the text at specific spots; gene synthesis is like writing the article from scratch...
https://www.nytimes.com/2021/11/24/magazine/gene-synthesis.html?smid=em-share

Monday, November 22, 2021

PHIL 3345-Spring 2022

 Returning to MTSU, January 2022-

PHIL 3345,
Dr. Phil Oliver-Office hours TTh 11:15-12:45 & by appt.
TTh 4:20-5:45 pm, James Union Building (JUB) 202
Supporting the philosophical study of bioethics, biomedical ethics, biotechnology, and the future of life, at Middle Tennessee State University and beyond... "Keep your health, your splendid health. It is better than all the truths under the firmament." William James
===

Our anchoring theme: the psychological and social dimensions of medicine and the life sciences from birth to death, with a special emphasis this semester on the ethics of pandemic and public health.

Texts 2022. We’ll begin with these texts:

  • Bioethics: The Basics (Campbell) ”...the word ‘bioethics’ just means the ethics of life…”  
  • Beyond Bioethics (Obasogie) “Bioethics’ traditional emphasis on individual interests such as doctor-patient relationships, informed consent, and personal autonomy is minimally helpful in confronting the social and political challenges posed by new human biotechnologies…”  
  • The Premonition (Lewis) "The characters you will meet in these pages are as fascinating as they are unexpected. A thirteen-year-old girl’s science project on transmission of an airborne pathogen develops into a very grown-up model of disease control. A local public-health officer uses her worm’s-eye view to see what the CDC misses, and reveals great truths about American society..."  
  • Lifelines: A Doctor's Journey in the Fight for Public Health (Wen) “Public health saved your life today—you just don’t know it” is a phrase that Dr. Leana Wen likes to use. You don’t know it because good public health is invisible. It becomes visible only in its absence, when it is underfunded and ignored, a bitter truth laid bare as never before by the devastation of COVID-19. 

 

Each student will also choose and report on an additional relevant texts pertaining to public health, thus enabling us to extend our study of the field by “crowd-sourcing” many more of the crucial issues it raises.

For more info contact phil.oliver@mtsu.edu

Saturday, November 13, 2021

Whether Patients Understand Is Beside the Point

Ending health disparities is too important a goal to cede to propagandists.

Last week, during a White House press briefing on COVID-19, CDC Director Rochelle Walensky urged Americans to get jabs for their kids. “We know that vaccination helps to decrease community transmission,” she said, “and protect those who are most vulnerable.”


Her message was succinct, accurate, and easy to understand. But it was at odds with new guidance from the American Medical Association and the Association of American Medical Colleges. In a document called Advancing Health Equity: A Guide to Language, Narrative and Concepts, the AMA and AAMC urge physicians and other health-care workers to replace many “commonly used” words, such as vulnerable, with “equity-focused” alternatives, such as oppressed...


https://www.theatlantic.com/ideas/archive/2021/11/leftist-language-policing-wont-fix-health-disparities/620695/?utm_source=email&utm_medium=social&utm_campaign=share

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Phil.Oliver@mtsu.edu
👣Solvitur ambulando
💭Sapere aude