Tuesday, March 29, 2022

A Plan to Reduce Mammal Use in Drug Development

 "Mount Desert Island Biological Laboratory, a non-profit research institute in Maine, is funding a new initiative to increase the use of non-mammalian models in early drug development. The initiative, dubbed MDI Bioscience, aims to turn to species like zebrafish (Danio rerio), C. elegans, axolotls (Ambystoma mexicanum), and African turquoise killifish (Nothobranchius furzeri) to evaluate potential therapeutic compounds at scale before they’re tested in mammals or enter human clinical trials, potentially hastening and honing the decision-making process in early drug discovery and reducing the reliance on mammals such as mice. MDI Bioscience hopes to evaluate drugs before money is spent on costly mammal research, to speed the drug development process, and reduce the number of mammals, and animals in general, used in scientific research. Jim Strickland, the director of MDI Bioscience, says that these goals are aligned the general research practice to reduce, replace, and refine (three R’s) animals in research. The three R’s seek to address the potential ethical issues involved in animal research, which become heightened in higher order animals like rodents and primates."

Thoughts? 

Also- if you need a mood boost, please google axolotls. I promise you will not be disappointed. 

2 comments:

  1. Is this a financial issue or an ethical issue for these biological companies? I'd assume that these model organisms are cheaper than using mammals and that is why they are advocating for the switch. I guess I'm confused on why using some animals could be considered more ethical than others.

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  2. Economically and ethically minded it makes sense to test drugs destined for humans on mammals similar to humans. Being someone who can draw a line, a human life is worth more than a mouse. If they think the tests will help spare the life of a mouse or two I guess if they think it is worth the trouble? To me it shouts insanity that they would want to run MORE tests on animals more different than humans. All it means is more creatures being involved in science and more responsibility.

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